It’s essential to follow medical guidance to avoid potential side effects and ensure the treatment is safe and effective. TRT works by supplying the body with synthetic or bioidentical testosterone to compensate for the deficiency. Men with low levels may feel too tired to exercise or engage in physical activities, leading to further weight gain. More muscle means a higher metabolic rate, which helps burn excess fat. "Research suggests that L-citrulline supplementation may improve vascular health and reduce blood pressure, but more studies are needed to confirm these effects and determine optimal dosages." – Dr. David Katz, M.D. This is an essential amino acid whose inclusion helps trigger the nitric oxide release in the body. It controls a lot of functions but most important is a sexual function, not to mention cognitive as well as the growth of muscles. Reports have indicated that some men will start to see a decreased testosterone level. Alpha T is a male enhancement supplement that acts as a testosterone booster. We do NOT intend for the information presented through our articles to replace the medical relationship with a qualified physician, nor does it represent specialized advice. Independent news platform delivering sharp analysis and fresh perspectives on USA, world affairs, politics, economy, tech, health, and more. One of the key observations in testosterone therapy is that testosterone increases LBM, thus increasing resting energy expenditure. In contrast, androgen deprivation therapy (ADT) used in management of hormone-dependent prostate cancer results in fatigue and reduces energy and motivation 95,97. Yu and Traish suggested that testosterone deficiency contributes to fatigue via alterations of mitochondrial function and energy production and utilization. Testosterone treatment results in improved insulin sensitivity, lipid oxidation and reduction in fat mass with concomitant gain in fat free mass. Testosterone levels are reduced with increased waist circumference and obesity 17,24 and approximately 40% of obese nondiabetic men and 50% of obese diabetic men aged above 45 years have low free testosterone 18,25. Because prostate cancer is so common, doctors tend to be leery of prescribing testosterone to men who may be at higher than average risk of having undiagnosed prostate cancer. Testosterone therapy does not appear to increase the risk of prostate cancer, but it can stimulate the growth of prostate cancer cells. As a result, there is some controversy about which men should be treated with supplemental testosterone. Men taking testosterone replacement must be carefully monitored for prostate cancer. I’m passionate about creating personalized workout programs that not only transform physiques but also empower individuals to live healthier, more confident lives. Stay on top of latest health news from Harvard Medical School. Sign up for HEALTHBeat and receive trusted health information delivered right to your inbox. Get the latest in health news delivered to your inbox! No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. However, the optimal amount of testosterone is far from clear. Men and women need the proper amount of testosterone to develop and function normally.